Allergy Immunotherapy Billing: How to Get Paid For All Your Serums

Dec 13, 2023
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Navigating the intricate world of immunotherapy billing can be as challenging as administering the treatment itself, especially for healthcare providers specializing in allergy immunotherapy. 


Understanding the nuances of billing components, such as serum preparation and injections, and adhering to specific Current Procedural Terminology (CPT) codes and unique billing guidelines is paramount. To add to the complexity, various insurance providers may necessitate specific diagnosis codes for accurate billing. 


In this comprehensive guide, we will delve into the core aspects of immunotherapy billing, ensuring you not only get paid for your essential serums but also secure the financial stability of your healthcare practice. We will also address pressing questions about immunotherapy costs, allowing you to understand the process thoroughly. So, whether you're looking to enhance your billing efficiency, avoid common pitfalls, or simply maximize your reimbursement, read on to master the art of allergy immunotherapy billing.

Understanding Immunotherapy Billing

 bottles of vaccine

Before we delve into the nitty-gritty, let's establish a clear understanding of immunotherapy billing first. Immunotherapy billing consists of two primary components: the preparation of the antigen serum and the injections administered to the patient. 


Each component has its own set of CPT codes and unique billing guidelines that can make the process challenging. To make matters more complex, insurance companies may require specific diagnosis codes to be used.


The Two Immunotherapy Billing Components


  • Serum Preparation: This involves the preparation of the antigen serum used in allergen immunotherapy. It includes codes like 95165 for multi-dose vials of non-venom antigens and 95144 for single-dose vials.
  • Injections: These are the codes used when the patient receives immunotherapy injections. They include codes like 95115 for a single injection and 95117 for multiple injections. It's important to note that you cannot bill codes 95115 and 95117 together; choose one that best represents the number of injections administered and bill only one unit of the selected code.

Serum Preparation Billing Codes:

  • 95165: Professional services for the supervision of preparation and provision of antigens for allergen immunotherapy; single or multiple antigens (specify the number of doses).
  • 95144: Professional services for the supervision of preparation and provision of antigens for allergen immunotherapy, single-dose vial(s) (specify the number of vials).

Stinging Insect Venom Billing Codes:


  • 95145-95149: Preparation and provision of antigens for allergen immunotherapy; stinging insect venom (select codes for the number of venoms).


The Importance of Proper Billing

Maintaining billing accuracy ensures you get paid on time and the right amount. But beyond the obvious reasons, there are numerous other benefits proper billing practices bring to your practice.


  • Financial Viability

Allergy immunotherapy can be a time-intensive and resource-demanding service. Without proper reimbursement, it can become financially unsustainable for healthcare providers. Accurate billing ensures you get compensated for the resources you invest in this treatment.

  • Compliance

Billing inaccuracies can lead to compliance issues. Ensuring that your billing practices align with regulations and guidelines helps you avoid legal troubles and potential fines.

  • Patient Satisfaction

Transparent and accurate billing practices improve patient satisfaction. Patients who understand their bills and insurance coverage are more likely to have a positive experience with your practice.

  • Streamlined Operations

Efficient billing practices can streamline your administrative processes, reducing the time and effort you spend managing billing-related tasks.


Common Billing Issues

how to get paid for non face to face medical time

Avoiding denials and ensuring you get paid for all your serums require attention to detail and adherence to billing best practices. It is essential to be aware of these common billing issues to avoid potential problems:


  • Not Verifying Insurance Coverage

Before starting any immunotherapy treatment, always verify the patient's insurance coverage. Check how many units are billable per year and if the treatment is covered for the patient's specific diagnosis and plan. This is especially important for Rush immunotherapy.

  • Not Properly Documenting Mixing Logs

Accurate documentation is crucial. Make sure to maintain detailed mixing logs, clearly listing each allergen separately and noting the date of mixing. Ensure that the document is signed off with the provider's signature, as it's considered incomplete without it.

  • Not Following Edits and Local Insurance Policy

Stay updated on the National Correct Coding Initiative (NCCI), Medically Unlikely Edits (MUE), and Local Coverage Determinations (LCD) that may affect your billing. Different insurances may have specific policies regarding the number of serum units billed per day or month.

  • Billing an Evaluation and Management (E/M) Code with Injections

Billing an E/M code on the same day as an injection is rare. There should be a clear and separate reason for providing the E/M service, distinct from the reasons for immunotherapy. Most insurance will require medical records and an appeal to pay for such cases.


Billing for immunotherapy allergy can be as intricate as the treatment itself, but it's a vital part of ensuring the financial stability of your healthcare practice. By understanding the components of immunotherapy billing, avoiding common pitfalls, and following best practices, you can enhance your billing processes and maximize your reimbursement.


Remember, accurate billing not only benefits your practice but also contributes to a positive patient experience. By mastering immunotherapy billing, you can continue to provide life-changing treatments to those in need while ensuring your practice's success. So, embrace these tips and best practices, and let your expertise shine in both patient care and billing efficiency.

Understanding Allergy Immunotherapy Cost: What You Need to Know

Allergy immunotherapy is a vital treatment for individuals suffering from allergies, offering long-term relief from bothersome symptoms and, in some cases, reducing the risk of severe allergic reactions. However, one common concern that both patients and healthcare providers share is the cost associated with allergy immunotherapy.


The Cost of Allergy Immunotherapy and its Influencing Factors:

1. Treatment Duration: The duration of allergy immunotherapy can vary from patient to patient. Typically, treatment is administered over several years, with varying frequencies of injections. This prolonged treatment period can influence the overall cost.

2. Insurance Coverage: Insurance coverage plays a significant role in determining the out-of-pocket cost for patients. Some insurance plans may cover the entirety of allergy immunotherapy, while others may require patients to contribute financially.

3. Treatment Type: There are different types of allergy immunotherapy, including subcutaneous (under-the-skin) injections and sublingual (under-the-tongue) tablets. The type of treatment chosen can impact costs, with sublingual options often being more expensive.

4. Geographical Location: The cost of healthcare services, including allergy immunotherapy, can vary based on the geographic location. Urban areas with higher living costs may have slightly higher treatment fees.

5. Medical Facility: The choice of a medical facility or healthcare provider can influence the cost of allergy immunotherapy. Specialized allergy clinics may have different pricing structures than general healthcare facilities.


Allergy immunotherapy can be a valuable investment in your long-term health and well-being. By understanding the factors that influence the cost and discussing your options with your healthcare provider, you can make informed decisions about pursuing this effective allergy treatment.

Why Choose DrCatalyst?

two women are looking at a clipboard with graphs on it .

Keeping the nuances of medical billing top of mind is not only impossible, it's also unnecessary, especially when you can easily get professional help from proven experts.


With DrCatalyst, your financial operations are in highly capable hands. Extensively trained for the U.S. healthcare system, our team of remote billers are experts in navigating the complexities of medical billing, including coding, insurance eligibility verification, accounts receivable, and more. With a special focus on compliance, we stay current with evolving regulations, reducing your risk from legal issues and maintaining smooth operations.


What sets DrCatalyst apart is our commitment to offering tailored solutions. Knowing that every practice is unique, we customize our services to seamlessly fit into your specialty workflow.

Embark on a journey toward improved financial viability with a team that shares your passion for excellence. Partner with DrCatalyst today!

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